Cobalt and possible oxidant-mediated toxicity
Identifieur interne : 001196 ( Main/Exploration ); précédent : 001195; suivant : 001197Cobalt and possible oxidant-mediated toxicity
Auteurs : Benoit Nemery [Belgique] ; Christian P. L. Lewis [Belgique] ; Maurits Demedts [Belgique]Source :
- Science of the Total Environment [ 0048-9697 ] ; 1994.
Abstract
The occurence of interstitial lung disease similar to hard metal lung disease in diamond polishers who had been exposed to cobalt (in the absence of tungsten carbide) through the use of polishing disks containing microdiamonds sintered with cobalt, led us to experimentally test the hypothesis that cobalt has pro-oxidant activity in lung tissue. Several experiments were carried out in which we measured indices of oxidant stress, mainly changes in the oxidation state of glutathione and in the activity of the pentose phosphate pathway, upon exposure of hamster pulmonary tissue to CoCl2 in vivo by intratracheal instillation, or in vitro by incubating lung slices. These experiments indicated that cobalt ions are capable of causing thiol oxidation in lung tissue as an early manifestation of oxidant stress, but more studies are needed to establish the relevance of this mechanism in the causation of lung disease in subjects exposed to cobalt-containing dusts.
Url:
DOI: 10.1016/0048-9697(94)90129-5
Affiliations:
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Several experiments were carried out in which we measured indices of oxidant stress, mainly changes in the oxidation state of glutathione and in the activity of the pentose phosphate pathway, upon exposure of hamster pulmonary tissue to CoCl2 in vivo by intratracheal instillation, or in vitro by incubating lung slices. These experiments indicated that cobalt ions are capable of causing thiol oxidation in lung tissue as an early manifestation of oxidant stress, but more studies are needed to establish the relevance of this mechanism in the causation of lung disease in subjects exposed to cobalt-containing dusts.</div></front></TEI><affiliations><list><country><li>Belgique</li></country></list><tree><country name="Belgique"><noRegion><name sortKey="Nemery, Benoit" sort="Nemery, Benoit" uniqKey="Nemery B" first="Benoit" last="Nemery">Benoit Nemery</name></noRegion><name sortKey="Demedts, Maurits" sort="Demedts, Maurits" uniqKey="Demedts M" first="Maurits" last="Demedts">Maurits Demedts</name><name sortKey="Lewis, Christian P L" sort="Lewis, Christian P L" uniqKey="Lewis C" first="Christian P. L." last="Lewis">Christian P. L. Lewis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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